Evidence map›Paper›PMID 40637967›Full record

ArticleBreast cancer research and treatment2025

Immediate and ipsilateral recurrence rates and treatment recommendations for patients with pleomorphic and florid lobular carcinoma in situ.

Lavinia P Middleton, George H Perkins, Gary J Whitman, Jason A Mouabbi, Therese B Bevers, Min Yi, Kelly K Hunt

Abstract read
PubMed Publisher
In one paragraph

Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lavinia P MiddletonDepartment of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 85, Houston, TX, 77030, USA. lpmiddleton@mdanderson.org.
George H PerkinsRadiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gary J WhitmanBreast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jason A MouabbiBreast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Therese B BeversClinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Min YiBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kelly K HuntBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

University of Texas MD Anderson Cancer Center Faculty funds
6 · The paper itself

Abstract

backgroundFollow-up data are limited regarding the natural history of patients diagnosed with pleomorphic lobular carcinoma in situ (PLCIS) and florid lobular carcinoma in situ (FLCIS).

methodsThis retrospective study identified patients with PLCIS and FLCIS. Clinicopathologic findings were evaluated. Patients with concurrently diagnosed ipsilateral breast cancer or ductal carcinoma in situ were excluded. The immediate and delayed risk of developing breast cancer was calculated.

resultsAll 45 patients were female, and the median age was 61 years. The most common imaging finding was suspicious calcifications on screening mammogram in 84.4%. The histology was PLCIS in 75.6% of cases (34/45), FLCIS in 11.1% (5/45), and a combination of variant types in 13% (6/45). Forty-four patients underwent surgery to include wide local excision in 84% (37/44) and mastectomy in 15.9% (7/44). One patient (2.3%) had concurrent DCIS on excision and ten patients (22.7%) had diagnoses upgraded to invasive carcinoma on excision, the majority being T1a (70%) and the remainder T1b (30%). These aforementioned patients were excluded from further outcome analysis. There were four patients (8.8%) with PLCIS who developed ipsilateral cancers in the same quadrant; of which two were local and two were local regional occurring 135, 106, 89, and 60 months after the initial diagnosis. All four patients had < 2 mm margins after initial surgery (p < 0.05).

conclusionsThere is both an immediate (24.4%) and delayed (8.8%) risk of breast cancer in patients diagnosed with PLCIS and FLCIS. Our data support excision to 2 mm margin and maintenance of long-term follow-up.

Indexed as

Breast Carcinoma In SituBreast NeoplasmsCarcinoma, LobularNeoplasm Recurrence, LocalAdultAgedAged, 80 and overFemaleHumansMammographyMastectomyMiddle AgedRetrospective StudiesBreastFlorid lobular carcinoma in situLobular carcinoma in situPleomorphic lobular carcinoma in situ

Identifiers

PMID40637967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.