Evidence map›Paper›PMID 40637957›Full record

ArticleMolecular neurobiology2025

Overexpression of mGlu

Geanne A Freitas, Kelly Weiss, Vaishnavi Bavadekar, Sheryl Anne D Vermudez, Nicole M Fisher, Aditi Buch, Shalini Dogra, Zixiu Xiang, Rocco G Gogliotti, Colleen M Niswender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Geanne A Freitas *Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Kelly Weiss *Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Vaishnavi Bavadekar *Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Sheryl Anne D VermudezDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Nicole M FisherDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Aditi BuchDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Shalini DograDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Zixiu XiangDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Rocco G GogliottiDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Colleen M NiswenderDepartment of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA. colleen.niswender@vanderbilt.edu.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Development of mGlu7 receptor allosteric modulators for neurological and psychiatric disordersR01MH124671 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG, NISWENDER, COLLEEN M · 2020 to 2024
$3.5M
A precision medicine approach to Rett SyndromeR01NS112171 · NINDS · LOYOLA UNIVERSITY CHICAGO · PI GOGLIOTTI, ROCCO GEORGE · 2020 to 2024
$1.7M
Stratifying Rett syndrome patient populations to evaluate the efficacy of genetic and pharmacological therapeutic interventionsF31MH119699 · NIMH · VANDERBILT UNIVERSITY · PI VERMUDEZ, SHERYL ANNE DAGUIMOL · 2019 to 2021
$91k
International Rett Syndrome Foundation Award 3903National Institute of Mental Health, Grant/Award Numbers F31MH119699National Institute of Mental Health, Grant/Award Numbers R01MH124671National Institute of Mental Health, Grant/Award Numbers R01NS112171NICHD NIH HHS P50 HD103537NIMH NIH HHS F31 MH119699NIMH NIH HHS R01 MH124671NINDS NIH HHS R01 NS112171
6 · The paper itself

Abstract

Metabotropic glutamate receptor 7 (mGlu

Indexed as

Neurodevelopmental DisordersReceptors, Metabotropic GlutamateAnimalsHippocampusHumansLong-Term PotentiationMaleMiceMice, Inbred C57BLMice, Transgenicmetabotropic glutamate receptor 7Receptors, Metabotropic GlutamateCognitionElectrophysiologyGlutamateHippocampusMetabotropicNeurodevelopmental disorders

Identifiers

PMID40637957
PMCPMC12511187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.