ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
The mechanism of Akkermansia muciniphila inhibiting the proliferation of colorectal cancer cells via ferroptosis.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
aimsRecent clinical studies have revealed a significant correlation between Akkermansia muciniphila (Akk) and colorectal cancer (CRC). To elucidate the fundamental mechanisms by which Akk inhibits the proliferation of CRC, this study applied pasteurized Akk, Akk metabolites, and their postbiotics on Caco-2 cells.
methodsCell proliferation, lactate dehydrogenase (LDH) release, and reactive oxygen species (ROS) levels were employed as screening indicators. Based on single-cell transcriptomics analysis, we investigated the mechanisms through which Akk inhibits the proliferation of Caco-2 cells. Finally, verification was conducted using three characteristic indicators: malondialdehyde (MDA), glutathione (GSH), and Fe2+, ferroptosis inhibitor (Fer-1) served as a control. Cell scratch assays and flow cytometry experiments are used to verify cell death.
resultsThe findings indicate that metabolites of Akk exert the most potent inhibitory effect on Caco-2 cells. Notably, there was a significant increase in LDH and ROS levels, while metabolic pathways associated with ferroptosis were markedly enriched. Furthermore, there was an increase in Fe2+ and MDA content accompanied by a decrease in GSH levels. Cell proliferation ability declined sharply, and a large number of cells die.
conclusionsThis study confirms that metabolites of Akk can indeed suppress CRC cell proliferation through the ferroptosis pathway.
Indexed as
Identifiers
40637947What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.