Evidence map›Paper›PMID 40637943›Full record

ArticleNeurosurgical review2025

Triglyceride-glucose index: an independent risk factor for all-cause mortality in critically ill aneurysmal subarachnoid hemorrhage patients- a retrospective analysis of the MIMIC-IV database.

Zhen Kun Xiao, Duan Yong Hong, Yi Bo Yang, Fei Yi Fan Wang, Xiao Fei Liu, Gong Duo, Jian Hua Liu, Bing Wang, Ai Hua Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhen Kun XiaoHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China.
Duan Yong HongHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China.
Yi Bo YangHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China.
Fei Yi Fan WangHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China.
Xiao Fei LiuHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China.
Gong DuoInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jian Hua LiuMedical Teaching Experiment Center, Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Bing WangHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China. wangb46@mail2.sysu.edu.cn.
Ai Hua LiuHengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421000, China. 16673498449@163.com.

Funding

Major Project of National Clinical Key Specialty, Hunan Provincial Health Commission 20230279Natural Science Foundation of China 81771233Natural Science Foundation of China 82100498Natural Science Foundation of Chinax NSFC82202891the Hunan Provincial Natural Science Foundation General Program 2022JJ30520
6 · The paper itself

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular event linked to high mortality and disability. The triglyceride-glucose index (TyG), a marker of insulin resistance, has not been thoroughly investigated for its impact on prognosis in ICU patients with aSAH. This study examines the association between TyG and all-cause mortality (ACM) in aSAH patients in the ICU. Data from the MIMIC-IV (version 3.0) database were used to identify severe aSAH patients via ICD-9/10 codes. Cox regression assessed the relationship between TyG and ACM, with restrictive cubic splines (RCS) and Kaplan-Meier curves for further analysis. Among 560 patients (55.2% female), the ACM rates were 18.1%, 23.3%, 24.1%, and 27.9% at overall, 30-day, 90-day, and 1-year follow-ups, respectively. Elevated TyG was independently associated with higher hospital ACM (aHR, 2.447; 95% CI, 1.416-4.228), 30-day (aHR, 2.998; 95% CI, 1.764-5.095), 90-day (aHR, 3.355; 95% CI, 1.983-5.676), and 1-year ACM (aHR, 4.298; 95% CI, 2.624-7.038). RCS showed a linear increase in risk as TyG exceeded 7.43. Subgroup analysis revealed stronger associations in those with cerebral parenchymal hemorrhage and pulmonary infections. TyG is an independent risk factor for ACM in critically ill aSAH patients. This study supports TyG as a prognostic tool for assessing mortality risk in these patients.

Indexed as

Blood GlucoseSubarachnoid HemorrhageTriglyceridesAdultAgedCritical IllnessDatabases, FactualFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsBlood GlucoseTriglyceridesAll-cause mortalityAneurysmal subarachnoid hemorrhageIntensive care unitMIMIC-IV databaseTriglyceride-glucose

Identifiers

PMID40637943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.