ArticleVeterinary research communications2025
Molecular epidemiology and phylogenetic analysis of Echinococcus spp. in the Qinghai-Tibetan Plateau: unraveling genetic evolution in a high-risk region for echinococcosis.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Three decades of research on molecular genetic characteristics of Echinococcus spp.: a bibliometric study.Folia parasitologica · 2026Review
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9 authors.
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Abstract
As the largest and highest plateau in the world, the Qinghai-Tibetan Plateau (QTP) also represents a critical endemic region for echinococcosis, a zoonotic disease caused by Echinococcus spp. The disease is listed as a neglected tropical disease by the World Health Organization (WHO). Given its high prevalence and associated socioeconomic impacts, there is an urgent need to conduct in-depth research on this problem and formulate prevention and control intervention strategies. Here, we conducted a molecular genetic analysis of 1299 samples (including canid feces and livestock hydatid cysts) from the QTP based on the mitochondrial cytochrome c oxidase I (COI) gene. Our results revealed the infection rate of echinococcosis had some regional differences and identified 24 distinct haplotypes that clustered into five Echinococcus species. Encouragingly, the first isolation and identification of Echinococcus equinus in Ovis aries laid the foundation for the cross-species transmission of Echinococcus. Phylogenetic analyses (ML/BI) consistently supported highly clustering of each haplotype with its reference sequence (bootstrap ≥ 80%, PP ≥ 0.80). Furthermore, molecular clock estimates indicated that the co-evolution of Echinococcus spp. and its host may be closely related to the rapid uplift and climate changes of the QTP since the Cenozoic era. This study provided the latest dataset on Echinococcus infections in natural hosts across the QTP, systematically revealing the epidemic characteristics, genotype distribution and genetic diversity of Echinococcus spp. in this region.
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