ArticleLangenbeck's archives of surgery2025
Do stricter criteria for intraoperative parathyroid hormone monitoring reduce the risk of persistence or reoperation in primary hyperparathyroidism? A receiver operating characteristic analysis.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Factors influencing identification accuracy rate of parathyroid glands using near-infrared autofluorescence during endoscopic thyroidectomy.Surgery open science · 2026Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntraoperative parathyroid hormone (PTH) measurement is a beneficial tool in the surgical management of primary hyperparathyroidism. The expected degree of intraoperative PTH reduction, which guides surgical decision-making, determines the sensitivity and specificity of this test. While stricter criteria may enhance diagnostic accuracy, an optimal threshold has not been conclusively established. The aim of this study was to identify the PTH reduction threshold that provides the highest sensitivity and specificity for achieving biochemical cure. PATIENTS AND
methodsA retrospective analysis was conducted on 141 patients who underwent parathyroidectomy for primary hyperparathyroidism, focusing on the intraoperative drop in PTH and surgical success. A receiver operating characteristic analysis was performed to identify the optimal threshold that balances sensitivity and specificity in predicting biochemical cure.
resultsThe mean percentage reduction at the end of surgery was 73.93% (SD ± 16.54%) with an overall cure rate of 94%. The area under the curve was 0.73 for a 50% PTH reduction, 0.77 for a 60% reduction, and 0.68 for a 70% reduction.
conclusionThe optimal balance between sensitivity and specificity was achieved with a 60% intraoperative PTH reduction. Stricter criteria increase sensitivity but may also raise the risk of surgical overtreatment.
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