ArticlePediatric cardiology2026
Relationships Between Adiposity Measures and Heart Rate Variability in Children and Adolescents.
Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiac autonomic dysfunction in children and adolescents with obesity: a systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Pooled it
- Morphological Correlates of Suppressed Autonomic Modulation: A Machine Learning Approach to Identifying Vagal Impairment Phenotypes in Women.Journal of functional morphology and kinesiology · 2026Article
- Early Referral of Individuals with Fontan Physiology to Heart Failure Specialists: A Fontan Action Plan.Pediatric cardiology · 2026Article
- Trends and regional disparities in hypoplastic left heart syndrome prevalence and mortality in the USA: a nationwide study.European journal of pediatrics · 2026Article
- Article
- Inflammation, Autonomic Control, and Adiposity in Adolescents: Links to Early Cardiovascular Risk.Life (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Understanding relationships between specific measures of adiposity and heart rate variability (HRV) allows for better understanding obesity as a risk factor for cardiovascular and autonomic dysfunction. We sought to examine associations between specific adiposity depots and cardiovascular autonomic function assessed via HRV among children and adolescents. We performed a secondary cross-sectional analysis of a previously completed study of 8-17-year-olds (n = 325; 12.4 ± 2.7 years). Adiposity was assessed via dual x-ray absorptiometry. Resting HRV measures included root mean square of successive differences (RMSSD), percentage of successive normal-to-normal intervals differing by more than 50 ms (pNN50), low frequency power (LF), high frequency power (HF), and low frequency-to-high frequency ratio (LF:HF). Associations between adiposity and HRV were evaluated using linear regression modeling, adjusting for sex and Tanner stage. RMSSD and pNN50 were both negatively associated with total fat (β = - 0.558, p = 0.004; β = - 0.178, p = 0.034), percent body fat (β = - 0.790, p = 0.007; β = - 0.296, p = 0.019), trunk fat (β = - 1.024, p = 0.004; β = - 0.344, p = 0.022), android fat (β = - 0.005, p = 0.006; β = - 0.002, p = 0.028), gynoid fat (β = - 0.003, p = 0.005; β = - 0.001, p = 0.034), visceral adipose tissue (β = - 0.013, p = 0.016; β = - 0.005, p = 0.038) and subcutaneous abdominal adipose tissue (β = - 0.007, p = 0.004; β = - 0.003, p = 0.017). RMSSD was negatively associated with appendicular fat (β = - 1.152, p = 0.008). Visceral adipose tissue was associated positively with LF and LF: HF (β = 0.004, p = 0.028; β = 0.019, p = 0.033) and negatively with HF (β = - 0.004, p = 0.028). We found that excess total and regional adiposity may have negative effects on cardiovascular autonomic nervous system function in a large cohort of children and adolescents. Longitudinal studies are needed to confirm and determine how these relationships change over time.
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