Oxygen dissociation curve inflection point during incremental exercise: a trigger for the Bohr effect.

Holger H Burchert, William W Stringer, Ranjan K Dash

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Inline dissolved-gas-derived oxygen saturation reference for dynamic blood phantoms at adult-head optical properties.Biomedical optics express · 2026
Article

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5 · Who and what money

Authors and funding

3 authors.

Holger H BurchertDepartment of Sport, Exercise and Health, University of Basel, Basel, Canton Basel, Switzerland. holger.burchert@unibas.ch.ORCID 0000-0001-9462-6175

William W StringerDepartment of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0003-2756-6728

Ranjan K DashDepartments of Biomedical Engineering and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6751-0679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously hypothesized that the inflection point of the oxygen dissociation curve (ODC) is linked to the gas exchange threshold (GET) during cardiopulmonary exercise testing. This hypothesis was supported by femoral venous blood gas data sampled during constant exercise below and above the GET, which showed that the ODC shifts rightward at the GET. What had gone unnoticed since these original observations in 1994 was that this rightward shift begins slightly earlier, precisely when the oxygen saturation crosses the ODC inflection point. To investigate this phenomenon, we analyzed the 1994 femoral venous blood gas data obtained during cardiopulmonary exercise testing using a modern validated mechanistic biochemical model of oxygen (O

Indexed as

ExerciseOxygenAdultCarbon DioxideExercise TestHemoglobinsHumansMaleOxygen ConsumptionPulmonary Gas ExchangeCarbon DioxideHemoglobinsOxygenAllosteric regulationAnaerobic thresholdCooperative oxygen bindingHaldane effectHill equationOxygen equilibrium curve

Identifiers

PMID40637854

DOI10.1007/s00424-025-03100-9

PMCPMC12310897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.