ArticleEndocrine2025
Benefits of a 12 weeks-individually tailored physical activity program in patients with Cushing's disease in remission and controlled acromegaly.
Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with controlled Cushing's disease (CD) and acromegaly (ACRO) often experience persistent musculoskeletal dysfunction and impaired quality of life (QoL) despite biochemical normalization. Although undergoing supervised physical activity is a clear unmet need of pituitary patients, evidence on the effectiveness of individually tailored exercise programs in these populations is scanty.
objectiveThe aim of this pilot study was to evaluate the effectiveness of a 12-week individually tailored and supervised exercise program on muscle function and patient-reported outcomes (PROMs) in patients with biochemically controlled CD and ACRO.
methodsTwenty patients (10 women with CD in remission, 10 men with controlled ACRO) participated in a structured program combining aerobic and resistance exercises, supervised by professional trainers, three times a week over 12 weeks. Outcomes assessed at baseline and post-intervention included, grip strength and physical performance on gait speed, timed up-and-go, chair stand test, muscle structure and quality on ultrasound examination and QoL, as evaluated using disease-specific (CushingQoL, AcroQoL) and generic (SF-12, PANAS, PHQ-9, and GAD-7) questionnaires.
resultsAfter the 12-week intervention, significant improvements were observed in physical performance tests (p < 0.05 for all parameters vs. baseline) in both CD and ACRO patients. Ultrasound-measured muscle thickness increased CD patients after completion of the program (p < 0.05), while a decreased echogenicity was found in ACRO patients (p < 0.05) CD patients demonstrated significant improvements in waist circumference, diastolic blood pressure (p < 0.05). No significant changes were observed in PROMs in either group after the intervention.
conclusionAn individually tailored, supervised, 12-week exercise intervention significantly enhanced muscle structure and physical performance in patients with controlled CD and ACRO. Further randomized controlled studies are required to confirm the clinical effectiveness of incorporating supervised exercise programs into multidisciplinary management for pituitary disease patients.
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