Evidence map›Paper›PMID 40637791›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2025

A Mind-Blowing Ingestion: Intentional Plastic Explosive Consumption Resulting in Seizures.

Seth Jones, Irene Li, Jasmine Gale, Elliott Fox, Stacy Weisberg, Stephanie Carreiro

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seth JonesDepartment of Emergency Medicine, Division of Medical Toxicology, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA. Seth.Jones@lahey.org.ORCID http://orcid.org/0009-0000-5205-8608
Irene LiDepartment of Emergency Medicine, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA.
Jasmine GaleDepartment of Emergency Medicine, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA.
Elliott FoxDepartment of Emergency Medicine, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA.
Stacy WeisbergDepartment of Emergency Medicine, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA.
Stephanie CarreiroDepartment of Emergency Medicine, Division of Medical Toxicology, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionC4 is a plastic explosive commonly used in military applications, and is predominantly composed of cyclonite or RDX (Royal Demolition Explosive). C4 toxicity is a documented but not commonly known cause of altered mental status and recurrent seizures. CASE REPORTS: We describe two cases of military personnel who ingested C4 as part of a hazing ritual who presented to the emergency department with witnessed seizure, tremor and petechial rash. One of the patients had a second witnessed seizure within hours of ingestion. They were treated with intravenous benzodiazepines acutely, then with levetiracetam for 48 hours. Both patients were observed in the intensive care unit and discharged with no neurologic sequelae. DISCUSSION: C4 is a common military-grade explosive containing cyclonite which functions as a non-competitive, reversible GABAA antagonist and a rare but clinically significant cause of altered mental status and seizures when ingested. Management is primarily supportive with airway protection and treatment with GABAergic medication.

Indexed as

Explosive AgentsPlasticsSeizuresAdultAnticonvulsantsBenzodiazepinesHumansLevetiracetamMaleMilitary PersonnelTreatment OutcomeYoung AdultAnticonvulsantsBenzodiazepinesExplosive AgentsLevetiracetamPlasticsIngestionMilitary personnelNeurotoxinRDXSeizure

Identifiers

PMID40637791
PMCPMC12511477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.