Evidence map›Paper›PMID 40637507›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.

Eivind Wang, Matthew J Rossman, H Jonathan Groot, Ryan S Garten, Catherine L Jarrett, Jan Helgerud, Jan Hoff, Russell S Richardson

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eivind WangFaculty of Health and Social Sciences, Molde University College, Molde, Norway.
Matthew J RossmanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.ORCID 0000-0001-9381-2590
H Jonathan GrootSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-5240-1680
Ryan S GartenDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, United States.ORCID 0000-0002-8939-6093
Catherine L JarrettDepartment of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington, United States.
Jan HelgerudMyworkout, Medical Rehabilitation Clinic, Trondheim, Norway.
Jan HoffMyworkout, Medical Rehabilitation Clinic, Trondheim, Norway.
Russell S RichardsonGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center (VAMC), Salt Lake City, Utah, United States.ORCID 0000-0003-0233-5923

Funding

Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Exercise and Cognitive Function in Alzheimers Disease Progression: Role of the Vascular EndotheliumR56AG057584 · NIA · UNIVERSITY OF UTAH · PI RICHARDSON, RUSSELL S. · 2018 to 2018
$658k
NHLBI NIH HHS T32 HL139451NIA NIH HHS R56 AG057584RRD VA I01 RX000182RRD VA I01 RX001697RRD VA I01 RX002323RRD VA I01 RX003207RRD VA I01 RX003810RRD VA I21 RX001433RRD VA IK6 RX003943U.S. Department of Veterans Affairs (VA) E1433-PU.S. Department of Veterans Affairs (VA) E1697-RU.S. Department of Veterans Affairs (VA) E6910-R
6 · The paper itself

Abstract

Regular physical activity and endurance exercise training prevent age-related vascular endothelial dysfunction in the arm in men. However, the effects of physical activity and/or endurance exercise training in the legs, which have a greater predisposition for vascular disease, have not been completely elucidated. This study sought to examine the impact of aging, physical activity, and endurance exercise training on leg vascular function in men. Flow-mediated dilation (FMD) of the superficial femoral and popliteal arteries (SFA and PA, respectively) was assessed in a total of 39 men, comprised of 10 young sedentary (Y; 23 ± 2 yr), 8 older sedentary (OS; 76 ± 8 yr), 9 older physically active (OA; 71 ± 8 yr), and 12 older endurance exercise trained (OT) subjects with exceptional aerobic exercise capacity (V̇o

Indexed as

AgingEndurance TrainingExerciseLegPhysical EnduranceAdultAgedEndothelium, VascularFemoral ArteryHumansMaleOxygen ConsumptionPopliteal ArteryRegional Blood FlowSedentary BehaviorVasodilationagingcardiovascular diseaseendotheliumflow-mediated vasodilationV̇o2max

Identifiers

PMID40637507
PMCPMC12366479

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.