ArticleJournal of neurophysiology2025
Timing- and frequency-specific effects of dentate nucleus deep brain stimulation on somatosensory-evoked potentials in people with poststroke hemiparesis.
Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Deep brain stimulation (DBS) of the dentate nucleus (DN) is being investigated as a therapy to enhance perilesional cortical excitability and promote motor recovery for individuals with chronic, poststroke motor deficits. Given that acute motor changes are not anticipated, DBS optimization would benefit from surrogate markers of stimulation's effect on cortical excitability. Here, we evaluate whether continuous and paired DN stimulation modulates somatosensory-evoked potentials (SSEPs), providing first in-human insight into their candidacy as a tool for device programming. SSEPs were collected from participants in a phase I DN DBS clinical trial to characterize the effects of continuous and paired stimulation on SSEP response characteristics. Continuous low-frequency DBS did not yield significant changes in short-latency peak-to-peak amplitude, though high-frequency stimulation yielded significantly lower peak-to-peak amplitude during double, but not single, pulse SSEP (64% of baseline,
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