ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Cytotoxic treatments pose a significant cardiotoxic risk to men with prostate cancer (PCa). Exercise has been found to prevent cardiotoxicities. Previous work from our group has also identified the chemopreventative effects of phellodendron amurense (PhAm). We therefore aimed to compare the effectiveness of exercise ± PhAm on cardiac function in a transgenic PCa mouse model. A 12-wk, four-arm, randomized controlled study was performed. Twenty-four transgenic adenocarcinoma of the mouse prostate mice were randomly assigned to either the control, exercise, PhAm, or exercise with PhAm (ExPhAm) treatment groups. Mice assigned to exercise were given continuous access to a running wheel. PhAm groups consumed a diet enriched with PhAm at 600 mg/kg. Control animals maintained a normal diet and activity. Pre-post echocardiography was performed to measure heart rate, interventricular septum (IVS) thickness, left ventricle (LV) internal diameter, LV volume, ejection fraction, fractional shortening, and left ventricle mass. Exercise, PhAm, and the combination were able to protect against an increase in end-diastolic and end-systolic LV mass (
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