Observational studyJournal of surgical oncology2025
The use of ROTEM in Detection of Coagulopathy and Altered Hemostasis in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Observational study in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Perioperative Coagulation Dynamics Assessed by ROTEM and Conventional Assays: A Prospective Longitudinal Study with Focus on Fibrinogen in Major Non-Cardiac Surgery.Journal of clinical medicine · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients undergoing Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are at risk of coagulopathy. This study aims to evaluate the potential role of rotational thromboelastometry (ROTEM) in detecting alterations in coagulation during and after CRS/HIPEC.
methodsA prospective observational study was conducted at a single tertiary care center. All consecutive patients undergoing CRS/HIPEC from April 2021 to December 2022 were enrolled. Participants were monitored using ROTEM, INR, PTT, and Fibrinogen at four time points (pre-incision, post-HIPEC, and on postoperative days 1 and 3).
resultsA total of 35 patients were included. Significant changes were observed from pre-incision to post-HIPEC coagulation parameters: mean fibrinogen decreased from 3.5 g/L to 2.1 g/L and mean INR increased from 1.1 to 2.1, p < 0.05. By postoperative day 3, all parameters had recovered to their pre-incision baselines, with EXTEM ML30 and fibrinogen significantly increased from baseline. Lower pre-incision fibrinogen was significantly associated with increased intra-operative blood loss, p < 0.05. Anesthesiologists reported that intra-operative ROTEM influenced management in 17% of cases (5/30).
conclusionsCRS/HIPEC is associated with significant changes in the coagulation profile that largely normalize by postoperative day 3. Utilizing ROTEM intraoperatively can help identify patients at risk of intra-operative bleeding and guide transfusion strategies.
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