Evidence map›Paper›PMID 40637319›Full record

ArticlemAbs2025

Epi4Ab: a data-driven prediction model of conformational epitopes for specific antibody VH/VL families and CDRs sequences.

Nhan Dinh Tran, Krithika Subramani, Chinh Tran-To Su

Abstract read
In one paragraph

Article in mAbs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nhan Dinh TranBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore.
Krithika SubramaniBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore.
Chinh Tran-To SuBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore.ORCID 0000-0001-6465-5987

Funding

the National Medical Research Council NMRC-OFYIRG (MOH-000661)
6 · The paper itself

Abstract

Antibodies recognize antigens via complementary and structurally dependent mechanisms. Therefore, inclusion of antibody inputs is crucial for accurate epitope prediction. Given the limited availability of antibody-antigen complex structures, any epitope prediction model will require minimal yet sufficient antibody inputs to ensure precise epitope identification. To address this need, we introduce Epi4Ab, an antibody-specific epitope prediction model that focuses on identifying unique in-contact antigen residues for a given antibody. Epi4Ab requires minimal antibody inputs, specifically VH/VL families and complementarity-determining region sequences.

Indexed as

Complementarity Determining RegionsEpitopesImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionHumansModels, MolecularComplementarity Determining RegionsEpitopesImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionAntibody-specific epitope predictionCDR sequencesconformational epitopegraph-based modelmachine learningVH-VL families

Identifiers

PMID40637319
PMCPMC12247109

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.