ReviewNucleic acids research2025
DBR1 orchestrates the fate of lariat RNA: debranching-dependent turnover and function.
Review in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Emerging strategies and innovations in circular RNA synthesis.Molecular therapy. Nucleic acids · 2026Review
- A functional connection between lariat debranching enzyme and spliceosome.Science China. Life sciences · 2026Article
- A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells.Nature biotechnology · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- CircRNAs: Novel biomarkers and therapeutic targets for diseases of the central nervous system.Biochemistry and biophysics reports · 2026Review
- Alternative Splicing Dysregulation in Retinitis Pigmentosa: Pathogenic Mechanisms and Therapeutic Opportunities.Biomolecules · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Lariat RNA, formed from excised introns during RNA splicing, is produced in molar amounts equal to mature messenger RNAs. As most genes contain introns in higher eukaryotes, lariat RNAs are inevitably generated and exhibit sequence diversity during gene expression. In general, lariat RNA is specifically debranched by the RNA debranching enzyme DBR1, followed by exonuclease-mediated degradation. DBR1 is the sole enzyme responsible for lariat RNA turnover. The recognition and debranching of lariat RNA by DBR1 is completely dependent on the existence of the branch structure with a 2'-5' phosphodiester bond. Surprisingly, recent advances have shown that some lariat RNAs can escape debranching and accumulate in a circular form from plants to mammals. We revisit the identification and functional regulation of DBR1, summarize the methods for defining and detecting lariat RNA, and highlight the extrinsic mechanisms and biological significance of DBR1-mediated lariat RNA debranching and lariat RNA retention. As an archetype of housekeeping noncoding RNAs, understanding lariat RNA turnover provides insights into the general properties of other noncoding RNA, especial circular RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.