Evidence map›Paper›PMID 40637209›Full record

Trial reportNeurorehabilitation and neural repair2025

Feasibility and Sensitivity of Wearable Sensors for Daily Activity Monitoring in Spinal Cord Injury Trials.

Melina Giagiozis, Irina Lerch, Anita D Linke, Catherine R Jutzeler, Rüdiger Rupp, Rainer Abel, Jesús Benito-Penalva, Josina Waldmann, Doris Maier, Michael Baumberger and 6 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase II
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03935321 (Antibodies Against Nogo-A to Enhance Plasticity, Regeneration and Functional Recovery After Spinal Cord Injury - A Multicenter International Randomized Double Blind Placebo Controlled Phase II Clinical Proof of Concept Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03935321 phase2completednot on this map

Antibodies Against Nogo-A to Enhance Plasticity, Regeneration and Functional Recovery After Spinal Cord Injury - A Multicenter International Randomized Double Blind Placebo Controlled Phase II Clinical Proof of Concept Trial

TypeinterventionalSponsorUniversity of ZurichRan2019 to 2023Enrolled129ConditionsSpinal Cord Injury, AcuteArmsNG-101, Placebos
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Melina GiagiozisSpinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland.ORCID 0009-0000-3818-259X
Irina LerchSpinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland.
Anita D LinkeSpinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland.
Catherine R JutzelerDepartment of Health Sciences and Technology (D-HEST), ETH Zurich, Zurich, Switzerland.
Rüdiger RuppSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-3873-1023
Rainer AbelClinic for Paraplegia, Klinikum Bayreuth GmbH, Bayreuth, Germany.
Jesús Benito-PenalvaInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Josina WaldmannOrthopädische Klinik, Hessisch Lichtenau, Germany.
Doris MaierSpinal Cord Injuries, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany.
Michael BaumbergerSwiss Paraplegic Centre, Nottwil, Switzerland.
Jiri KrizSpinal Cord Unit, Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.ORCID 0000-0002-3334-3646
Andreas BadkeBG Clinic Tübingen, Tübingen, Germany.
Margret Hund-GeorgiadisClinic of Neurorehabilitation and Paraplegiology, REHAB Basel, Basel, Switzerland.ORCID 0000-0002-4415-2888
Norbert WeidnerSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
László DemkóSpinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland.ORCID 0000-0001-5677-2331
Armin CurtSpinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland.

Funding

Swiss National Science Foundation
6 · The paper itself

Abstract

BackgroundThe aim of clinical trials for spinal cord injury (SCI) is to improve everyday-life activity outcomes, which requires reliable methods for monitoring patient activity. This study evaluates sensor-derived activity metrics in comparison to established clinical assessment methods.MethodsWearable inertial sensors collected data from 69 individuals with acute, traumatic cervical SCI participating in the Nogo-A Inhibition in Spinal Cord Injury trial (NCT03935321), a phase 2b, multicenter, randomized, placebo-controlled trial. During inpatient rehabilitation, participants wore up to 5 inertial sensors for up to 3 consecutive days each week. An estimation of average daily energy expenditure (EE) was used as an indicator of physical activity and compared to the recovery of Upper Extremity Motor Scores (UEMS) and Spinal Cord Independence Measures (SCIM).ResultsParticipants in the

Indexed as

AccelerometryActivities of Daily LivingEnergy MetabolismOutcome Assessment, Health CareSpinal Cord InjuriesWearable Electronic DevicesAdultFeasibility StudiesFemaleHumansMaleMiddle Ageddaily activity monitoringenergy expenditureIMUsinertial measurement unitsspinal cord injury

Identifiers

PMID40637209
PMCPMC12476463

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.