Evidence map›Paper›PMID 40637207›Full record

ArticleMolecular ecology2025

DNA Methylation Reflects Cis-Genetic Differentiation Across the European Crow Hybrid Zone.

Justin Merondun, Jochen B W Wolf

Abstract read
In one paragraph

Article in Molecular ecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Epigenetic signatures of migratory orientation in a songbird hybrid zone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Justin MerondunDivision of Evolutionary Biology, LMU Munich, Martinsried, Germany.ORCID https://orcid.org/0000-0001-5077-4096
Jochen B W WolfDivision of Evolutionary Biology, LMU Munich, Martinsried, Germany.ORCID https://orcid.org/0000-0002-2958-5183

Funding

Deutsche Forschungsgemeinschaft WO 1426/2-1 (JBWW)European Research Council ERCStG-336536 FuncSpecGen (JBWW)Knut och Alice Wallenbergs Stiftelse Project Grant (JBWW)Ludwig-Maximilians-Universität München
6 · The paper itself

Abstract

Chromatin modifications provide a substrate for epigenetic variation with evolutionary potential. To quantify the contribution of this layer of variation during speciation in crows, we leveraged genome and methylome sequencing data from an incipient avian species: all-black carrion crows, grey-coated hooded crows, and their hybrids. Combining controlled experimentation under common garden conditions and sampling of natural genetic variation across the hybrid zone, we show that 5mC methylation variation was largely explained by genome properties and the ontogenetic programme of the organism. Taxonomically related methylation divergence clustered in intergenic space, with the only genomic region of strongly elevated genetic differentiation encoding the diagnostic colour contrast between taxa. We conclude that methylation variation with relevance to speciation largely follows cis-genetic polymorphism in this system and does not constitute an autonomous axis of evolution.

Indexed as

CrowsDNA MethylationGenetic VariationAnimalsEuropeGenetic SpeciationHybridization, GeneticDNA methylationevolutionary epigeneticsgenomicshybridizationspeciation

Identifiers

PMID40637207
PMCPMC12573725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.