Evidence map›Paper›PMID 40636956›Full record

ArticleCirculation research2025

GPR146 Facilitates Blood Pressure Elevation and Vascular Remodeling via PIEZO1.

Zhenzhen Chen, Haizeng Zhang, Wendong Li, Qianhui Ling, Wenwen Cong, Yue Deng, Ke Chen, Shuangyue Li, Changting Cui, Wenjie Wang and 2 more

Abstract read
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In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Hypertensive mt. tRNARedox biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zhenzhen Chen *Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, China (Z.C., H.Z., Q.L., J.C.).ORCID 0000-0001-9919-3997
Haizeng Zhang *Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, China (Z.C., H.Z., Q.L., J.C.).ORCID 0000-0002-1500-9265
Wendong Li *Department of Vascular Surgery, The Affiliated DrumTower Hospital, Nanjing University Medical School, Jiangsu, China (W.L., K.C.).ORCID 0000-0001-8344-419X
Qianhui LingBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, China (Z.C., H.Z., Q.L., J.C.).ORCID 0000-0003-4812-3934
Wenwen CongState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (H.Z., W.C., Y.D., C.C., W.W., B.G.).
Yue DengState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (H.Z., W.C., Y.D., C.C., W.W., B.G.).ORCID 0000-0001-9717-9163
Ke ChenDepartment of Vascular Surgery, The Affiliated DrumTower Hospital, Nanjing University Medical School, Jiangsu, China (W.L., K.C.).ORCID 0000-0001-9354-5197
Shuangyue LiDepartment of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Germany (S.L.).
Changting CuiState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (H.Z., W.C., Y.D., C.C., W.W., B.G.).ORCID 0000-0002-5056-3608
Wenjie WangState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (H.Z., W.C., Y.D., C.C., W.W., B.G.).ORCID 0000-0003-4179-4137
Bin GengState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (H.Z., W.C., Y.D., C.C., W.W., B.G.).ORCID 0000-0001-7573-8710
Jun CaiBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, China (Z.C., H.Z., Q.L., J.C.).ORCID 0000-0002-8928-9570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is a prevalent chronic disease worldwide. Elevated hydrostatic pressure (HP) is the main feature of hypertension. GPCRs (G-protein-coupled receptors) are crucial for vascular tone and a significant pharmacological target for drug development. Here, we aimed to identify the key GPCR under high HP, and explore its role and mechanism in hypertension and vascular remodeling.

methodsFirst, RNA-seq was performed under high HP and identified the highly expressed GPCR-GPR146. Furthermore, global knockout GPR146 mice, vascular smooth muscle cell (SMC)-specific knockin and knockout GPR146 mice were used to explore its function in hypertension. Next, an HP loading system ex vivo was established to evaluate the role of GPR146 in response to HP. Vascular SMC-specific

resultsUnder high HP, we identified a highly expressed GPCR-GPR146 in vascular SMCs by RNA-seq and confirmed it in the arterial media of patients with hypertension and animal models. Functionally, overexpression or deletion of

conclusionsCollectively, GPR146 coupled with Gα

Indexed as

blood pressurehydrostatic pressurehypertensionreceptors, G-protein–coupledvascular remodeling

Identifiers

PMID40636956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.