ArticleResearch and practice in thrombosis and haemostasis2025
Investigating interassay variability between direct oral anticoagulant calibrated anti-factor Xa assays: a substudy of the perioperative anticoagulation use for surgery evaluation (PAUSE) trial.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays.Research and practice in thrombosis and haemostasis · 2025Article
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7 authors.
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Abstract
Background: Direct oral anticoagulant calibrated anti-factor Xa (FXa) assays can assess residual anticoagulant levels in patients requiring urgent procedures or surgery. However, previous studies have shown variability between anti-FXa levels determined by different instrument-reagent combinations. This may be related to use of lyophilized samples, direct oral anticoagulant-spiked plasma, or interlaboratory variation. Objectives: 1) Determine the interassay variability in anti-FXa levels using 3 common instrument-reagent combinations. 2) Determine if differences between these combinations are clinically relevant. Methods: Seventy apixaban and 59 rivaroxaban samples from participants in the Perioperative Anticoagulation Use for Surgery Evaluation trial were simultaneously tested using Biophen reagents on the BCS XP analyzer (Siemens), HemosIL reagents on the ACL TOP analyzer (Werfen), and Stago reagents on the STA CompactMAX analyzer (Diagnostica Stago). Interassay correlations were analyzed at the predetermined cutoff of 30 ng/mL and compared with median anti-FXa levels. Results: Anti-FXa levels showed moderate-to-very strong correlations for apixaban ( Conclusions: Anti-FXa levels determined by 3 common instrument-reagent combinations show moderate-to-very strong correlations with each other. Although there are statistically significant differences between median anti-FXa levels these differences are not clinically significant, and result in discrepant classification across the 30 ng/mL threshold in only 7.8% of samples.
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