ArticleFrontiers in cardiovascular medicine2025
Identification of left atrial wall thickness in substrate mapping of atrial fibrillation.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Three-Dimensional Left Atrial Geometry in Atrial Fibrillation: Imaging Biomarkers, Substrate Phenotyping, and Ablation Outcome Prediction.Diagnostics (Basel, Switzerland) · 2026Review
- Relationships between three-dimensional fibrosis distribution, atrial adiposity, and voltage abnormalities associated with persistent atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The objective of this study was to assess the clinical relevance of left atrial wall thickness (LAWT) in identifying electrophysiological substrate abnormalities. Methods: Eighty-two patients with atrial fibrillation undergoing first-time catheter ablation at Xuzhou Central Hospital between March 2016 and May 2023 were enrolled in this study. The left atrium was anatomically segmented into five regions, with all patients undergoing delayed gadolinium-enhanced magnetic resonance imaging (LGE-MRI) for quantitative assessment of parameters including left atrial wall thickness (LAWT, epicardial fat excluded). Bipolar voltage mapping was systematically performed to delineate low-voltage zones (LVZs) and calculate their relative area proportion within the total atrial surface for each patient. The regional segmentation method for left atrial voltage mapping was consistent with that used in late gadolinium-enhanced magnetic resonance imaging (LGE-MRI). Univariate and multivariate logistic regression analyses were conducted to identify clinical factors associated with LVZ formation. Receiver operating characteristic (ROC) curve analysis was employed to determine the optimal LAWT cutoff value for LVZ prediction, along with its corresponding sensitivity and specificity. Additionally, regional comparative analyses were performed between LGE-MRI-derived wall thickness measurements and their corresponding low-voltage zones identified by three-dimensional electroanatomic mapping. Results: The study cohort comprised 82 atrial fibrillation patients (44 paroxysmal AF, 38 persistent AF). Mean LAWT significantly differed between paroxysmal and persistent AF groups (2.6 ± 0.5 mm vs. 2.3 ± 0.4 mm, Conclusions: This study demonstrate that LAWT significantly correlate with both atrial fibrillation progression and electroanatomical remodeling. Notably, regions exhibiting LAWT ≤ 2.3 mm predict more extensive LVZs. Our findings suggest that non-invasive LGE-MRI-based measurement of LAWT may enhance the detection rate of left atrial pathological substrates.
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