ArticleEuropean heart journal. Imaging methods and practice2025
High levels of pericoronary adipose tissue inflammation are associated with coronary atherosclerosis independent of epicardial adipose tissue volume in patients with chronic coronary syndrome.
Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mediation of stenosis-induced ischemia by proximal peri-coronary adipose tissue: A cross-sectional study.Medicine · 2026Article
- Relationship between epicardial fat tissue, endothelial function, and coronary flow reserve in coronary microvascular disease patients.Cardiovascular ultrasound · 2026Article
- Pericoronary fat attenuation index on coronary CT angiography and cardiovascular risk in patients with coronary artery disease and chronic kidney disease.BMC nephrology · 2025Article
- Association of metabolic dysfunction-associated fatty liver disease with coronary CT angiography-derived plaque characteristics and cardiovascular events.BMC medical imaging · 2025Article
- Plant-derived natural products targeting inflammation in treatment of atherosclerosis.Frontiers in pharmacology · 2025Review
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Authors and funding
16 authors.
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Abstract
Aims: This study aimed to assess clinical risks and coronary atherosclerotic burden in patients with chronic coronary syndrome (CCS) stratified by pericoronary artery adipose tissue (PCAT) composition and epicardial adipose tissue volume (EAV). Methods and results: We retrospectively included 410 CCS patients who underwent coronary computed tomography angiography. Patients were divided into four groups based on an EAV index ≥ 73.5 mL/mm Conclusion: Elevated PCAT inflammation is associated with the coronary plaque burden independent of EAV index in patients with CCS. Lay summary: • This study demonstrates that distinct phenotypes based on ectopic fat volume and composition-the volume of epicardial adipose tissue (EAT) and the inflammation status of pericoronary adipose tissue (PCAT)-can characterize coronary atherosclerotic disease burden in patients with chronic coronary syndrome.• While both increased EAT volume and PCAT inflammation have been reportedly associated with coronary artery disease (CAD) and cardiovascular events, evidence investigating the association of EAT volume and PCAT inflammation with CAD disease burden is limited.• Patients with increased EAT volume are at an elevated risk for coronary artery calcification and increased plaque burden, regardless of PCAT inflammation. In contrast, among patients without increased EAT volume, increased PCAT inflammation is correlated with an increased risk of coronary artery calcification and plaque burden.
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