ArticleJournal of Indian Society of Periodontology
Estimation of the salivary levels of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α in periodontitis patients with and without diabetes in comparison to systemically and periodontally healthy individuals.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Multivariate analysis of treatment choices, disease activity, comorbidities, and oral impairments in rheumatoid arthritis patients.Journal of Indian Society of PeriodontologyArticle
- Estimation and comparison of salivary matrix metalloproteinase-9 and S100A8 levels in reverse smokers, smokers, and non-smokers with periodontitis.Journal of Indian Society of PeriodontologyArticle
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Abstract
Background: Early identification of periodontal disease, mainly in diabetic patients, is crucial for the prognosis and treatment planning. Biochemical signaling during periodontal disease involves the production of cytokines. Chemokines belong to the group of chemotactic cytokines that are able to activate and migrate a variety of cells, like bone cells and leukocytes, which stimulate inflammatory events. Chemotactic chemokines, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 alpha (MIP-1α) are secreted by different types of cells. These salivary biomarkers might be of use in assessing periodontal disease presence, risk and progression, especially in diabetic patients. Materials and Methods: Thirteen milliliters of unstimulated whole saliva were collected from five groups: Systemically and periodontally healthy individuals, gingivitis patients without diabetes, periodontitis patients without diabetes, periodontitis patients with diabetes, and periodontally healthy diabetic individuals. The samples were then centrifuged at 2600 rpm for 15 min at 4°C, and the supernatant was kept at - 80°C until additional analysis. The enzyme-linked immunosorbent assay was used to examine the amounts of MCP-1 and MIP-1α in the saliva. Results: Levels of MCP-1 and MIP-1α were significantly higher in periodontitis with diabetes group ( Conclusion: The present study illustrates that salivary biomarkers MCP-1 and MIP-1α might be promising biomarkers in differentiating periodontal disease from health, especially in diabetic individuals.
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