ArticleJournal of Indian Society of Periodontology
Comparative evaluation of the efficacy of "advanced platelet-rich fibrin plus" and enamel matrix derivative on proliferation and migration of periodontal ligament fibroblasts - An
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Epigenetic memory in periodontal healing: mechanisms, evidence, and emerging therapeutic perspectives.Odontology · 2026Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Background: Platelet concentrates and enamel matrix derivatives (EMD) have been used extensively for periodontal regenerative procedures. Modifications in processing protocols have resulted in a variety of concentrated platelet formulations. The present study evaluated the combination of a modified platelet concentrate, advanced platelet-rich fibrin plus (A-PRF+), with Emdogain Materials and Methods: The study utilized an Results: Increased cell migration and proliferation were observed from 24 to 48 h in all the groups with significant wound closure. After 48 h, the A-PRF+ and EMD group showed complete wound closure and the highest proliferation rate compared to either EMD or A-PRF+ alone, and distilled water. Conclusion: The combined application of A-PRF+ and EMD promoted enhanced wound healing, surpassing the effects of EMD and A-PRF+ used individually. The study also demonstrated the superior ability of EMD alone in periodontal fibroblast healing. Cell migration and proliferation propensity of A-PRF+ endorse it as an option for regenerative therapy.
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