SynthesisFrontiers in oncology2025
Impact of the microcystic, elongated, and fragmented invasion pattern on prognosis in endometrial carcinoma: a comprehensive meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognostic significance of the microcystic, elongated, and fragmented (MELF) invasion pattern in endometrial carcinoma (EC) has not been fully elucidated. This study conducted a systematic search across five electronic databases (PubMed, EMBASE, Cochrane, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI)) from inception to April 2025. Assessment focused on overall survival (OS), disease-free survival (DFS), lymph node metastasis (LNM), and recurrence rate (RR) as primary outcomes. Meta-analysis calculations of overall odds ratios (ORs) and hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) elucidated the impact of the MELF pattern on clinical outcomes. Analysis of 18 studies involving 5587 participants revealed a significant correlation between the presence of MELF pattern and heightened LNM incidence (OR 3.52, 95% CI: 2.17-5.71, p < 0.001). Univariate analysis indicated a notable inverse relationship between MELF pattern and OS (HR 2.31, 95% CI: 1.67-3.21, p < 0.001), as well as DFS (HR 1.67, 95% CI: 1.20-2.30, p = 0.002). In multivariate analysis, however, this association did not achieve statistical significance (for OS, HR 1.54, 95% CI: 0.99-2.41, p = 0.056; for DFS, HR 1.25, 95% CI: 0.90-1.74, p = 0.191). The findings of this meta-analysis demonstrated that the MELF pattern was linked to elevated risk of LNM and poorer OS and DFS outcomes. The correlation was influenced by various factors including surgical interventions and adjuvant therapies. While potentially increasing the risk of recurrence, the findings did not demonstrate statistical significance (OR 1.15, 95% CI: 0.61-2.16; p = 0.669).
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