ArticleFrontiers in oncology2025
Dose and local efficacy analysis of iodine-125 seed implantation therapy for lung tumors.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Seven-year follow-up demonstrating sustained survival followingOncology letters · 2026Article
- Multiphysics finite element analysis of vertebral stability in simulated osteolytic lumbar defects treated withFrontiers in bioengineering and biotechnology · 2026Article
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Authors and funding
7 authors.
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Abstract
Objective: To explore the dose and local efficacy of iodine-125 seed implantation therapy for lung tumors. Methods: The clinical data of 85 patients with lung tumors who underwent iodine-125 seed implantation therapy were retrospectively analyzed. The impact of prescription dose D90 (minimum peripheral dose received by the 90% target volume) on the local treatment effect six months after seed implantation was analyzed, and the critical value for predicting efficacy was determined. Factors affecting the local complete response (CR) rate six months after surgery were also analyzed. Results: The local control rate at six months after treatment was 89.41% (76/85), and the objective response rate (ORR) was 70.59% (60/85), with a CR rate of 31.76% (27/85). Patients with a post-procedure D90 > 140 Gy had a significantly higher local CR rate. Multivariate analysis revealed that post-procedure D90 and tumor size were independent prognostic factors for achieving CR six months after lung tumor seed implantation. Conclusion: Iodine-125 seed implantation therapy is effective for lung tumors. Tumor size (
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