Diagnostic value of CT radiomics and clinical features in differentiating focal organizing pneumonia from peripheral lung cancer.

Objective: This study aimed to evaluate the diagnostic value of computed tomography (CT) radiomics combined with clinical characteristics in differentiating focal organizing pneumonia (FOP) from peripheral lung cancer (PLC). Methods: A total of 60 FOP patients admitted between June 2023 and June 2024 were included as the FOP group, while 60 PLC patients were assigned to the PLC group. General clinical and imaging data were collected for both groups. Logistic regression analysis was employed to identify independent risk factors for FOP. Radiomics features were extracted from CT images of FOP patients, and the Lasso method was used to select key radiomics features and calculate CT radiomics scores. The diagnostic performance of CT radiomics and clinical characteristics for FOP was assessed using receiver operating characteristic (ROC) curve analysis. Results: There were no statistically significant differences in age, gender, lung tissue boundary, pleural indentation sign, vascular convergence sign, pleural traction sign, or bronchial air sign between the FOP and PLC groups ( Conclusion: Pleural adhesion, lesion location in the outer lung zone, liquefaction necrosis, cavity formation, and long spiculation are key risk factors for FOP. Both CT radiomics and clinical characteristics can aid in the differentiation of FOP from PLC, and their combination significantly enhances diagnostic accuracy.