ArticleCureus2025
Electrocardiographic T-wave Abnormalities and Premature Ventricular Contraction Burden in Patients With Palpitations: A Regional Study From Northeast India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundPremature ventricular contractions (PVCs), often presenting as palpitations, are common in cardiology outpatient settings. While a high PVC burden is linked to adverse cardiac outcomes, its detection typically requires 24-hour Holter monitoring - an investigation not always feasible in resource-limited settings. Electrocardiographic (ECG) markers of ventricular repolarization, represented by T-wave abnormalities, such as Tp-Te interval, Tp-Te/QT ratio, and QTc dispersion, may serve as accessible surrogate indicators of PVC burden.
objectiveTo evaluate the correlation between surface ECG-derived repolarization markers and PVC burden and determine which parameters best predict higher PVC burden in patients presenting with palpitations. METHODOLOGY: A total of 87 adult patients with palpitations referred to a tertiary care cardiology clinic in Northeast India underwent 12-lead ECG and 24-hour Holter monitoring. Patients were stratified into two groups based on PVC burden (<1% vs. >1%). ECG parameters, including T-wave axis angle, frontal QRS-T (fQRS-T) angle, Tp-Te interval, Tp-Te dispersion, Tp-Te/QT ratio, and QTc dispersion, were compared. Statistical analysis included Welch's t-test and Spearman's correlation.
resultsTp-Te interval (
conclusionsAmong surface ECG markers studied, Tp-Te interval, Tp-Te/QT ratio, and QTc dispersion showed the strongest correlation with PVC burden in patients presenting with palpitations. These accessible and non-invasive markers may help identify patients at risk of higher PVC loads who may benefit from further evaluation, especially in settings where Holter monitoring is limited.
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