Evidence map›Paper›PMID 40636590›Full record

ArticleJBMR plus2025

Hypophosphatasia and neuropathic pain: related to vitamin B6 metabolism?

Zografia Zervou, Evert F S van Velsen, M Carola Zillikens

Abstract readCase Reports
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. External validation of the proposed diagnostic criteria for hypophosphatasia in adults of a Spanish cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zografia ZervouErasmus MC Bone Center, Department of Internal Medicine, Erasmus University Medical Center, 3015 GD, Rotterdam, The Netherlands.ORCID https://orcid.org/0009-0008-5277-6202
Evert F S van VelsenErasmus MC Bone Center, Department of Internal Medicine, Erasmus University Medical Center, 3015 GD, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-6938-065X
M Carola ZillikensErasmus MC Bone Center, Department of Internal Medicine, Erasmus University Medical Center, 3015 GD, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-9186-3423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypophosphatasia (HPP) is caused by pathogenic variant(s) of the

Indexed as

ALPLhypophosphatasianeuropathic paintissue-nonspecific alkaline phosphatasevitamin B6

Identifiers

PMID40636590
PMCPMC12234444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.