Evidence map›Paper›PMID 40636569›Full record

ArticleiLIVER2023

Altered expression in liver cancer with various hepatic blood flow occlusions: A pilot RNA sequencing study.

Xuning Wang, Lili Zhang, Maolin Xu, Bin Shi

Abstract read
In one paragraph

Article in iLIVER, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xuning WangDepartment of General Surgery- Anus & Intestine Surgery, The Air Force Hospital of Northern Theater PLA, Shenyang 110092, China.
Lili ZhangDepartment of Organ Transplantation Management, The Third Medical Center of PLA General Hospital, Beijing 100039, China.
Maolin XuDepartment of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Bin ShiDepartment of Organ Transplantation, The Third Medical Center of PLA General Hospital, Beijing 100039, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Hepatocellular carcinoma is one of the most common cancers worldwide. Previous studies have reported he influence of various hepatic blood flow occlusions on tumor behavior, which is mainly mediated by liver ischemia-reperfusion. Although some genes and pathways have been determined, the whole transcriptome after various hepatic blood flow occlusions is lacking. Methods: We systematically explored transcriptome changes after various hepatic blood flow occlusions, including sham operation (SO; Results: HE sections and TUNEL assays showed different liver injury among groups. We identified the top altered genes and pathways. Compared with the SO group, 96 genes were altered in OPV, with 81 upregulated and 15 downregulated genes. The top 5 upregulated genes were Conclusion: Various surgical methods have an obvious influence on the transcriptome of tumors.

Indexed as

Hepatic blood flow occlusionLiver cancerTranscriptome

Identifiers

PMID40636569
PMCPMC12212675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.