ArticleJournal of pediatrics. Clinical practice2025
Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study.
Article in Journal of pediatrics. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objective: We investigated if specific carbohydrate blood group antigens were associated with infant botulism (IB) among discordant twins and triplets. Study design: Infants in the US and Canada from 2015 to 2022 who had laboratory-confirmed IB; were members of a multiple gestation birth; and had unaffected sibling(s), were eligible to participate. Blood specimens were tested for ABO, Lewis, H, and P1 carbohydrate blood antigens. Results: Parents of 14 of 26 IB cases who were twins or triplets with unaffected siblings consented to participate. No statistically significant associations between blood group antigens (ABO, Lewis, H, and P1) and IB were demonstrated. Twin cases in this study were significantly younger at onset of illness (median age 8.6 vs 17.3 weeks for the singleton US-Canadian IB cases, Conclusions: In this first-of-its-kind small study of IB twin or triplet cases and their unaffected siblings, no carbohydrate blood group antigens were associated with IB. Future studies could compare the microbial composition of the gut microbiome of IB cases and uninfected twin siblings or the prevalence of ABO blood groups in IB cases vs population norms.
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