ReviewHealth science reports2025
Understanding the Intersection Between Hormonal Dynamics and Brain Plasticity in Alzheimer's Disease: A Narrative Review for Implementing New Therapeutic Strategies.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Gut Microbiota-Sex-Immunity Axis in Non-Communicable Diseases.Life (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Alzheimer's disease (AD), a chronic neurodegenerative disorder, is portrayed by neurocognitive decline in the structure and function of the human brain. Various factors are implicated in the pathogenesis to neuroplasticity alteration in the brain of an individual afflicted with AD. The subset of these elements known as "hormonal dynamics" is paramount in the pathophysiology of AD. This review dives into the complex relationship between hormonal dynamics and brain neuroplasticity with special handling of AD considering the impediments and opportunities for the implementation of therapeutic strategies. Methods: A comprehensive review was conducted using online search databases PubMed/Medline and ScienceDirect, identifying-with a thematic approach-articles handling the interaction between the hormonal fluctuation and neuroplasticity in AD with special consideration sought from the emerging therapeutic strategies. Results: This review reveals the influence of various hormonal fluctuations, including estrogens and androgens, on neuroplasticity alteration in the structure and function of the brain in AD. Furthermore, the forms of neuroplasticity and synaptic plasticity processes are significantly altered with underlying neuronal loss and cognitive impairment in AD. Therefore, pharmacological and nonpharmacological therapy approaches as virtual reality and repetitive transcranial magnetic stimulation (rTMS), that promote synaptic plasticity advancements, play a key role in decreasing the rate of deterioration and progression in AD. Conclusion: Apprehending the intricate interactions between hormonal dynamics and neuroplasticity of the brain is necessary for advancing targeted therapeutics for AD. Upcoming studies should be directed toward the pathophysiological mechanism of hormonal neuroprotection and regeneration with the long-term effects of hormonal replacement therapies, advocating personalized management plans. It should also work on identifying specific imaging and biological markers for the monitoring of HRT. Furthermore, other influences such as environmental, epigenetic, physical, and psychological illness should be tackled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.