ArticleCancer innovation2025
Global Trajectories of Colorectal Cancer Burden From 1990 to 2021 and Projection to 2040.
Article in Cancer innovation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights.Health care science · 2026Review
- Hypoxia Associated Integration of Epigenetic, Metabolic, and Immune Biomarkers in Blood and Urine for Early Colorectal Cancer Detection: A Multimarker Panel.Diagnostics (Basel, Switzerland) · 2026Article
- A 5-fluorouracil-loaded BSA-Pd nanozyme inducing ROS burst and mild photothermal therapy for potent eradication of colorectal cancer.Scientific reports · 2026Article
- Macrophage-associated prognostic modeling uncovers immunotherapy response mechanisms and defines HAGHL as a novel oncogenic driver in breast cancer.Frontiers in immunology · 2026Article
- Tumor tissue-associatedFrontiers in cellular and infection microbiology · 2026Article
- Hemoglobin-Albumin-Lymphocyte-Platelet Score as an Integrative Biomarker for Prognosis and Sarcopenia in Colorectal Cancer.Journal of inflammation research · 2025Article
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13 authors.
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Abstract
Background: There is significant heterogeneity in patterns of colorectal cancer burden, which is still not well understood. This study examines global trajectories in the colorectal cancer burden, explores associated factors, and predicts future trends. Methods: Data on the colorectal cancer burden for 204 countries and territories from 1990 to 2021 were sourced from the Global Burden of Disease Study. Growth mixture models identified subgroups of age-standardized incidence and mortality rates. Eleven modifiable risk factors and four socioeconomic determinants were analyzed across the subgroups. Trends to 2040 were predicted using a Bayesian age-period-cohort model. Results: Three trajectories of colorectal cancer burden were observed: slowly increasing, rapidly increasing, and slowly decreasing age-standardized incidence rate, corresponding to stable, increasing, and decreasing mortality rate. Most countries showed slowly increasing incidence rates (49.0%, Conclusion: Global disparities in colorectal cancer burden highlight the need for targeted interventions, particularly focusing on dietary factors and health inequities.
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