Evidence map›Paper›PMID 40636397›Full record

ArticleJAC-antimicrobial resistance2025

Novel approach in treatment of

Neha Gupta, Vikas Agashe, Rajeev Soman, Kandarp Vidyarthi, Rajiv Gupta, Ishita Sen, Mrinalini Koley, Balaji Veeraraghavan, Kailash Gupta

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neha GuptaDepartment of Infectious Diseases, NG Swastha and Fortis Memorial Research Institute, Gurugram, India.
Vikas AgasheDepartment of Orthopaedics, P. D. Hinduja and Agashe Hospital, Mumbai, India.
Rajeev SomanDepartment of Infectious Diseases, Jupiter Hospital, Pune, India.
Kandarp VidyarthiDepartment of Orthopaedics, Paras Hospitals, Gurugram, India.
Rajiv GuptaDepartment of Radiology, Medanta, The Medicity, Gurugram, India.
Ishita SenDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Mrinalini KoleyDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Balaji VeeraraghavanDepartment of Clinical Microbiology, Christian Medical College, Vellore, India.
Kailash GuptaGeneral Surgeon, Teerath Nursing Home, Rewa, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Melioidosis, caused by Objectives: To report a novel case of Methods: A 59-year-old man presented with radial osteomyelitis requiring multiple rounds of surgical debridement. Severe allergic reactions to trimethoprim/sulfamethoxazole and ceftazidime, and meropenem-associated leukopenia made traditional therapies unfeasible. Levonadifloxacin was introduced as a salvage therapy, leveraging its efficacy against Conclusions: Levonadifloxacin emerged as the salvage therapy for this patient, achieving significant clinical improvement without relapse after more than 6 months of therapy cessation, despite the life-threatening combination of melioidosis-associated osteomyelitis and antibiotic intolerance. This first reported use of levonadifloxacin in melioidosis underscores its potential as an alternative therapy in such complex infections. Aggressive surgical intervention and tailored antimicrobial strategies remain crucial to overcoming these dual challenges.

Identifiers

PMID40636397
PMCPMC12238538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.