SynthesisFrontiers in medicine2025
A bibliometric analysis of studies related to the nuclear factor kappa B signaling pathway in knee osteoarthritis between 2004 and 2023.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exosome therapy for knee osteoarthritis: a network meta-analysis based on rat models.Stem cells translational medicine · 2026Article
- Target-Specific Extracorporeal Shockwave Therapy Modulates TLR4/NF-κB/MMP13 Signaling Within the Joint Microenvironment to Improve Osteochondral Pathology in Patellofemoral Osteoarthritis.International journal of medical sciences · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to identify the principal research areas and trends in the nuclear factor kappa B (NF-κB) signaling pathway in knee osteoarthritis (KOA). Methods: The Web of Science core collection (WoSCC) database was searched for studies related to the NF-κB signaling pathway in KOA published between 2004 and 2023. The complete records of the literature and all citations were exported from the WoSCC database to plain text file and tab-delimited file, respectively. The exported data were then analyzed. Analysis was conducted using CiteSpace (version 1.6.20) and VOSviewer (version 6.1. R6), OriginPro 2021 (version 9.8.0.200), SCImago Graphica (version 1.0.44), and the bibliometric website (http://bibliometric.com/). Results: A total of 752 studies were included in this analysis, and the results demonstrated an overall increasing trend in the number of published papers and citation frequency over the period 2004-2023. China leads in terms of the number of publications, with 387 publications, followed by the United States (118), and Japan (45). The institutions with the highest number of publications were China Medical University (28) and The Second Affiliated Hospital of Wenzhou Medical University (Yuying Children's Hospital) (24). The most frequently occurring keywords were "articular cartilage," "inflammation," "activation," and "expression." Furthermore, recent keywords with high research intensity included "histopathology," "mesenchymal stem cells," "subchondral bone," and "hip." Toll-like receptor 4 (TLR4), monosodium iodoacetate (MIA), and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) were popular research topics. Conclusion: The bibliometric analysis revealed that studies of NF-κB signaling pathways in KOA have predominantly focused on the TLR4/NF-κB signaling pathway and exosomes. NF-κB plays a core regulatory role in KOA, with molecular evidence supporting its involvement in inflammation, cartilage degradation, and pain signaling. However, current research is limited by the lack of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.