ReviewFrontiers in medicine2025
Mapping and visualization of global research progress on autophagy in metabolic dysfunction-associated steatotic liver disease and metabolic syndrome: a bibliometric analysis (2009-2024).
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to delineate the current trends and hotspots in autophagy research related to metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), with the aim of guiding future investigations in this area. Methods: This study extracted research on autophagy in MetS and MASLD from the Web of Science Core Collection (WoSCC) database. Review articles were systematically excluded to focus on original research contributions. A bibliometric analysis and visualization were conducted using VOSviewer 1.6.20, CiteSpace 6.3.R1, and R 4.3.3. Results: The study included 1,114 articles from 1,220 institutions across 42 countries/regions, demonstrating a significant increase in research output from 2009 to 2024. China led with 506 publications, followed by the USA and Korea. The Egyptian Knowledge Bank constitutes a consortium of institutions operating within the national research framework, with one institution designated as the primary publishing entity. Notably, the journal Nature has emerged as the most frequently cited publication. Singh Rajat received the highest number of citations (3,610), while Marycz Krzysztof was the most prolific author. The most cited article, published in 2009, was titled "Autophagy regulates lipid metabolism." Keyword trends have shifted from earlier topics such as "phosphorylation" and "gene-expression" to more recent terms like "lipid accumulation" and "mitophagy." Burst keyword analysis indicated that "liver fibrosis," "modulation," "gut microbiota," and "lipotoxicity" have emerged as significant topics. Conclusions: This study has elucidated the protective role of autophagy in MASLD and MetS. Future research is anticipated to concentrate on the activation of autophagy in the context of natural product drug discovery, the exploration of underlying molecular mechanisms, the regulation of fatty acid metabolism, and the development of functional nutritional supplements, among other relevant areas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.