ArticleFrontiers in medicine2025
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peptic ulcer disease (PUD) arises from an imbalance between harmful factors like gastric acid and pepsin, and the protective mechanisms of the gastrointestinal lining, particularly the mucus-bicarbonate barrier. Standard treatments include proton pump inhibitors (e.g., lansoprazole) and histamine H₂-receptor antagonists (e.g., ranitidine), but these can have adverse effects. Aim: To evaluate the gastroprotective effects and underlying mechanisms of Methods: A dose-response study was conducted using rats divided into six groups: naïve, ulcer control, and four groups treated with Results: The 10 mg/kg dose was most effective in reducing gastric ulceration. The extract reduced gastric acid secretion, like H₂ blockers. It also showed stronger antioxidant activity in gastric tissues compared to lansoprazole and ranitidine. Additionally, it reduced pro-inflammatory cytokines (IL-1 Conclusion:
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