Evidence map›Paper›PMID 40636357›Full record

ArticleFrontiers in medicine2025

Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation.

Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Ting Huang, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao and 2 more

Abstract read
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In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manzhen Liao *Academy of Pediatrics, University of South China, Changsha, Hunan, China.
Taoyue Yao *Department of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.
Yonghui XieDepartment of Ultrasound, The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Shelby KuttyPediatric and Congenital Cardiology, Taussig Heart Center, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Jinqiao LiuDepartment of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.
Wei PengAcademy of Pediatrics, University of South China, Changsha, Hunan, China.
Ting HuangDepartment of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.
Huaiyang ChenAcademy of Pediatrics, University of South China, Changsha, Hunan, China.
Haoqin FanDepartment of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.
Zhenghui XiaoDepartment of Intensive Care Unit, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.
Qiming LiuDepartment of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
Yunbin XiaoDepartment of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary arterial hypertension is a severe and life-threatening disease characterized by a progressive increase in pulmonary vascular resistance. Catheter-based pulmonary artery denervation (PADN) has been conducted in pulmonary arterial hypertension patients; however, if stereotactic body radiotherapy (SBRT) can become a new non-invasive way to conduct, PADN has not been elucidated. Methods: A total of 12 healthy male New Zealand rabbits were digitally marked on their foreheads and randomly divided into the control group ( Results: The SBRT procedure was successfully performed in all six rabbits. Compared to the control group, SBRT-PADN reduced pulmonary artery systolic pressure and mean pulmonary artery pressure in ATEPAH rabbits. Meanwhile, SBRT-PADN could attenuate pulmonary artery dilatation in ATEPAH rabbits. Histological examination revealed evident structural damages in sympathetic nerves of SBRT-PADN animals, including vacuolization, nuclear pyknosis, and digestion chambers. No adverse events had been observed, and sparing of pulmonary artery of the intima and media was detected up to 90 days post-procedure. Conclusion: SBRT could destroy sympathetic nerves around pulmonary artery locally, which may represent a novel option for performing PADN. In addition, this study provided its short-term effectiveness and safety.

Indexed as

acute thromboembolic pulmonary arterial hypertensionpulmonary arterial hypertensionpulmonary artery denervationstereotactic body radiotherapysympathetic nerves

Identifiers

PMID40636357
PMCPMC12238088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.