ArticleFrontiers in medicine2025
Trends and emerging frontiers of mesenchymal stem cells in intervertebral disc degeneration: a bibliometric analysis (2000-2024).
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antioxidant biomaterials in intervertebral disc regeneration: current status and future clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Rebuilding the degenerative disc microenvironment: mesenchymal stem cells, exosomes, and bioengineered scaffolds.Frontiers in bioengineering and biotechnology · 2026Review
- Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intervertebral disc degeneration (IVDD) is a major global cause of disability, and mesenchymal stem cell (MSC) therapy offers a promising regenerative solution by targeting the root causes of degeneration, unlike conventional symptom-focused treatments. This bibliometric analysis explores trends and emerging research areas in MSC applications for IVDD. Methods: A comprehensive literature search was conducted in the Web of Science Core Collection database, covering publications from 2000 to 2024. Bibliometric and visualized analysis was performed using VOSviewers, CiteSpace and the R package "Bibliometrix." Results: This bibliometric analysis reviewed 931 articles, revealing an overall upward trend in publication activity. Leading authors included Sakai Daisuke, Grad Sibylle, and Alini Mauro. China and the USA led in publication volume and citation counts, while the United Kingdom achieved the highest average citations per publication. The University of Pennsylvania and Zhejiang University were the most productive institutions. Key journals included Conclusion: This bibliometric analysis revealed key research focuses on foundational biological mechanisms, translational applications, and addressing specific challenges in the use of MSC for IVDD. Future research is likely to focus on optimizing MSC functionality, developing cell-free therapies such as extracellular vesicles, and targeting the molecular mechanisms involved in disc degeneration and regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.