Evidence map›Paper›PMID 40636260›Full record

ReviewFrontiers in cellular and infection microbiology2025

The role of innate immune system in respiratory viral infection related asthma.

Xiao Wu, Feifei Huang, Wenbo Yao, Zheng Xue

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao Wu *Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Feifei Huang *Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenbo YaoKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, China.
Zheng XueShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between viral infections and asthma has garnered significant attention in recent years. Accumulating evidence suggests that viral infections can trigger asthma exacerbations, while asthma may also influence the susceptibility to viral infections, thereby creating a cycle of worsening symptoms and recurrent asthma attacks. Given that asthma is predominantly driven by Type 2 immune responses and viral infections are typically associated with Type 1 immune responses, the innate immune cells and cytokines that participate in both conditions appear to be the critical bridge connecting these two processes. In particular, innate immune cells play a pivotal role in modulating the immune response at the interface of viral infections and asthma. In this review, we summarize the key innate immune cells and cytokines involved in viral infections and asthma, highlighting their immunoregulatory mechanisms. We aim to provide novel perspectives and potential therapeutic directions for the clinical management of recurrent asthma attacks induced by viral infections.

Indexed as

AsthmaImmunity, InnateRespiratory Tract InfectionsVirus DiseasesAnimalsCytokinesHumansCytokinesasthmacytokinesinnate immune cellsrecurrent asthma attacksviral infection

Identifiers

PMID40636260
PMCPMC12237907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.