Evidence map›Paper›PMID 40636218›Full record

ArticleBioinformation2025

Regulation of inflammaging.

Francesco Chiappelli, Lily Fotovat, Allen Khakshooy, Oluwadayo Oluwadara, Jaden Penhaskashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesco ChiappelliDental Group of Sherman Oaks, Sherman Oaks, CA 91403.
Lily FotovatBoston University, Boston, MA 02118.
Allen KhakshooyDepartment of Internal Medicine, Valley Hospital Medical Center, Las Vegas, NV 89106.
Oluwadayo OluwadaraOluwadara Dental Corporation, 9612 East Foothill Blvd, Suite 100, Rancho Cucamonga, CA 91730.
Jaden PenhaskashiDivision of West Valley Dental Implant Center, Encino, CA 91316.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the α7-nicotinic acetylcholine receptor (α7-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)-3 chaperone protein. The point is made in this writing that therapeutic stimulation of the non-neuronal cholinergic system via, for instance, transcutaneous vagal stimulation, pharmaco-therapeutic activation of α7-nAChR/RIC-3, or stimulation of the pathway by other means, including microRNA treatment interventions could down-regulate states of inflammation such as the cytokines storm and chronic systemic inflammation in aging -

Indexed as

Acetylcholine (ACh)caspase activation and recruitment domain (CARD)cholinergic anti-inflammatory pathway (CHAIP)cyclic GMP-AMP synthase linked to a stimulator of interferon genes (cGAS-STING)host cell-associated damage-associated molecular patterns (DAMPs)inflammasomeleucine-rich repeat (LRR)metalloproteinase-8 (MMP8)MicroRNAs (miRs)non-neuronal cholinergic system (NNCS)nucleotide-binding oligomerization domain (NOD)nucleotide leucine-rich repeat-containing receptors (NLRs)pathogen-associated molecular patterns (PAMPs)pattern recognition receptors (PRRs)pyrin "cell death fold" (PYD) domainresistance to inhibitors of cholinesterase-3 (RIC-3)α7 nicotinic acetylcholine receptor (α7-nAChR)

Identifiers

PMID40636218
PMCPMC12236562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.