Linking hypoxia-inducible factor (HIF)-1α and HIF-2α expression in head and neck cancer.

Pratiksha Kumar, Megha Prabhakar, Shilpa Motghare, Arpita Srivastava, Karandeep Singh, Meena Jain, Megha Patel

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Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Pratiksha KumarDepartment of Oral Pathology and Microbiology, Government College of Dentistry Indore, Madhya Pradesh, India.

Megha PrabhakarDepartment of ENT, SRVS Medical College Shivpuri, Madhya Pradesh, India.

Shilpa MotghareDepartment of Pathology, SRVS, Government Medical College, Shivpuri, Madhya Pradesh, India.

Arpita SrivastavaDepartment of Oral Medicine and Radiology, Government College of Dentistry Indore, Madhya Pradesh, India.

Karandeep SinghDepartment of Oral & Maxillofacial Surgery, SGT University, Budhera Village, Gurugram, Haryana-122505, India.

Meena JainDepartment of Public Health Dentistry, Santosh Dental College, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India.

Megha PatelDepartment of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India.

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6 · The paper itself

Abstract

Hypoxic conditions often occur in solid tumors like those of the head and neck area, thus enhancing tumor evolution while causing both therapeutic resistance and worsening clinical outcomes. Therefore, it is of interest to evaluate the expression of HIF-1α and HIF-2α proteins to correlate with clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Hence, 80 patients with HNSCC participated in this study. The laboratory analysis of tumor tissue, conducted through immunohistochemistry, revealed the expression levels of HIF-1α and HIF-2α. The examined tissues were categorized into low, moderate, and high expression categories based on immunoreactivity scoring. The clinical outcomes of head and neck cancer patients become worse when producers of HIF-1α and HIF-2α elevate in their tumors.

Indexed as

biomarkerhead and neck cancerHIF-1αHIF-2αHypoxia-inducible factorimmunohistochemistryprognosis

Identifiers

PMID40636217

DOI10.6026/973206300210703

PMCPMC12236566

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