Evidence map›Paper›PMID 40636108›Full record

ReviewFrontiers in immunology2025

Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines.

Chengyu Hu, Chenguang Niu, Xiaohui Li, Ke He, Mengyu Li, Xiaonan Gao, Qiannan Wei, Weiyang Sun, Yongkun Zhao, Yuanguo Li and 4 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chengyu Hu *Henan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Chenguang Niu *Henan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Xiaohui Li *Henan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Ke HeInstitute of Traditional Chinese Medicine, School of Pharmacy, Henan University, Kaifeng, China.
Mengyu LiInstitute of Traditional Chinese Medicine, School of Pharmacy, Henan University, Kaifeng, China.
Xiaonan GaoInstitute of Traditional Chinese Medicine, School of Pharmacy, Henan University, Kaifeng, China.
Qiannan WeiHenan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Weiyang SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Yongkun ZhaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Yuanguo LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Xianzhu XiaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Zhiguang RenHenan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Xiaodong LiHenan Province Engineering Technology Research Center of Intelligent Diagnosis and Treatment, The First Affiliated Hospital, School of Basic Medicine Sciences, Henan University, Kaifeng, China.
Tiecheng WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 and seasonal influenza have taken a huge toll on the global economy and global health. Given the potential of COVID-19 to transform into a chronic epidemic akin to seasonal influenza, the influenza virus and SARS-CoV-2 will continue to be a significant threat to healthcare for some time to come. Coinfection involving the two viruses has been proven to worsen the severity of the illness, as evidenced by clinical observational data. Vaccination remains the most effective measure in the prevention and treatment of infectious diseases. In addition, the coadministration of influenza virus and SARS-CoV-2 vaccines offered greater benefits than either vaccine alone. Combination vaccines are also a major hotspot in novel vaccine development. This review highlights the advancements in the development of combined vaccines for COVID-19 and seasonal influenza, as demonstrated in animal studies and clinical trials, and emphasizes the importance of a combined vaccine.

Indexed as

CoinfectionCOVID-19COVID-19 VaccinesInfluenza, HumanInfluenza VaccinesSARS-CoV-2AnimalsClinical Trials as TopicHumansVaccines, CombinedCOVID-19 VaccinesInfluenza VaccinesVaccines, Combinedcoadministrationcoinfectioncombination vaccinesinfluenza virusSARS-CoV-2

Identifiers

PMID40636108
PMCPMC12238597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.