Evidence map›Paper›PMID 40636001›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2025

High expression of prostaglandin EP4 receptor mRNA in feline head and neck squamous cell carcinoma.

Margaret L Musser, Raquel Doke, Austin K Viall, Rachel L Phillips, Olufemi Fasina, Chad M Johannes

Abstract read

In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margaret L MusserDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Raquel DokeDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Austin K ViallDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Rachel L PhillipsDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Olufemi FasinaDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Chad M JohannesDepartment of Veterinary Clinical Sciences, (Musser, Doke) and Department of Veterinary Pathology (Phillips), Iowa State University, College of Veterinary Medicine, Ames, Iowa, USA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA (Viall); Colorado State University, Flint Animal Cancer Centre, Fort Collins, Colorado, USA (Johannes).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline head and neck squamous cell carcinoma (HNSCC) has limited treatment options. Previous studies suggest inflammation, mediated by cyclooxygenase-2 and prostaglandin E2 (PGE2), may play a developmental role. PGE2 signals through 1 of 4 receptors: EP1, EP2, EP3, and EP4. Increased expression of EP4 is associated with the development of multiple human and canine cancers but has not been evaluated in feline neoplasms. The objective of this study was to describe the mRNA expression of the EP4 receptor gene

Indexed as

Cat DiseasesGene Expression Regulation, NeoplasticHead and Neck NeoplasmsReceptors, Prostaglandin E, EP4 SubtypeRNA, MessengerSquamous Cell Carcinoma of Head and NeckAnimalsCatsFemaleMaleReceptors, Prostaglandin E, EP4 SubtypeRNA, Messenger

Identifiers

PMID40636001

PMCPMC12236091

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.