ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology2025
TMPO-AS1-hsa-let-7b-5p-EZH2-RNA network predicts poor survival in basal-like breast cancer patients.
Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The role of circulating MiR-34a-5p and MiR-let7a-5p as a diagnostic tumor markers in breast cancer a cross-sectional analysis.Molecular biology reports · 2026Article
- A pan-cancer atlas of metabolic regulatory circuitries integrating multi-omic, immune, and clinical dimensions.Frontiers in molecular biosciences · 2026Article
- Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives.Discover oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The study explores the role of non-coding ribonucleic acids (ncRNAs) and higher enhancer of zeste homolog 2 (EZH2) gene in breast cancer progression, examining how microRNA (miRNA) and long noncoding RNA (lncRNA) control EZH2, potentially influencing oncogene growth and treatment failure. Materials and methods: The databases used in the study included Cyclebase 3.0 and CellTracer to determine EZH2's role in cell cycle, Oncomine, OncoMX and The University of Alabama At Birmingham Cancer Data Analysis Portal (UALCAN) for Pan-cancer analysis, The Cancer Genomic Atlas Portal (TCGA Portal), Gene Expression Profiling Interactive Analysis (GEPIA2), OncoDB, CR2Cancer, Encyclopaedia of RNA Interactomes (ENCORI), and The Cancer Genome Altas Analyzer (TCGAnalyzeR v1.0) for differential expression analysis, CR2Cancer, OncoDB, MethMarkerDB, and Wanderer databases for epigenetic alteration analysis, Kaplan-Meier Plotter for survival analysis, Breast Cancer Gene Expression Miner (bc-GenExMiner v5.0) for hormone receptor analysis, Tumor-Immune System Interaction Database (TISIDB), Cancer Single Cell State Atlas (CancerSEA), TNMplot, DriverDBv4, and ENCORI for biological processes, cell cycle checkpoints and metastasis analysis, Enrichr, Tumor Immune Estimation Resource (TIMER 2.0), Gepia2 for transcription factor analysis, miRNet, Transcriptome Alterations in Cancer Omnibus (TACCO), and CancerMIRome for miRNA analysis, Enrichr, UALCAN, and ENCORI for lncRNA analysis. Results: The EZH2 gene is overexpressed in breast cancer (BRCA) tumors, metastatic tissues, and circulating tumor cells, potentially leading to cancer progression. Patients with high EZH2 expression have shorter overall survival (OS), distant metastasis-free survival (DMFS), and relapse-free survival (RFS) compared to those with low expression. Estrogen receptot (ER)-negative BRCA tumors and PR-negative tumors have high EZH2 gene and eukaryotic transcription factor (E2F2) levels. The EZH2/E2F2 axis may assist ER/PR-negative BRCA by sponging homosapiens microRNA family (hsa-let-7b-5p) through lncRNA-thymopoietin antisense transcript 1 (TMPO-AS1). Overexpression of the EZH2 protein is associated with BRCA metastasis. Conclusion: EZH2 overexpression in basal-like BRCA is mediated by a competing endogenous RNA (ceRNA) network and regulating their expression levels may facilitate better survival outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.