ArticleOpen forum infectious diseases2025
Development of a Diagnostic Score for Histoplasmosis in a Cohort of Patients With HIV.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Disseminated histoplasmosis is more common in patients with impaired immune function, with HIV infection being a recognized risk factor for its development. In this patient group, diagnosis poses a challenge due to the nonspecific clinical picture. We aimed to develop a diagnostic predictive scale for disseminated histoplasmosis in patients with HIV. Methods: We analyzed records from 2 tertiary institutions in the city of Pereira between May 2014 and December 2022. We selected 313 cases of HIV: 90 patients were diagnosed with histoplasmosis and 223 with other opportunistic infections. Results: Variables associated with the diagnosis of histoplasmosis were hemoglobin <10 g/dL (odds ratio [OR], 2.0; 95% CI, 1.0-4.2; Conclusions: This study proposes a simple and cost-effective tool that facilitates timely diagnosis and treatment of histoplasmosis in patients with HIV.
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