ArticleFrontiers in nutrition2025
Association of blood trace minerals and nocturia in young and middle-aged adults: a cross-sectional study based on NHANES.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The mechanism underlying nocturia in young and middle-aged individuals remains unclear. This study aimed to investigate the association between blood levels of trace minerals and the occurrence of nocturia. Methods: This cross-sectional study utilized data from the 2021-2023 National Health and Nutrition Examination Survey (NHANES). Linear regression models and subgroup analyses were employed to assess the relationship between blood concentrations of trace minerals including lead, cadmium, total mercury, manganese, and selenium and nocturia. Dose-response relationships were analyzed using smoothed curve fitting. Results: A total of 2,099 participants were included in the analysis. In unadjusted regression models, blood levels of cadmium and manganese were significantly and positively associated with nocturia in young adults, whereas blood selenium levels were significantly and inversely associated. These associations remained statistically significant after adjusting for relevant covariates in multivariate linear regression analyses. Subgroup analysis revealed that among participants who reported alcohol consumption, those with higher blood cadmium levels had a significantly increased risk of nocturia (OR = 1.626, 95% CI: 1.305-2.026, Conclusion: Blood levels of cadmium, manganese, and selenium are significantly associated with nocturia in young and middle-aged adults. These findings suggest that urologists should consider the potential role of trace mineral levels in the prevention and management of nocturia.
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