ArticleFrontiers in nutrition2025
Modified life's essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- AI digital-twin ecosystem translating gut-microbiome-neuroimmune signals into precision sleep-mood interventions.Frontiers in psychiatry · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: The research sought to examine the correlation between the dietary index for gut microbiota (DI-GM) and sleep disorders. The specific relationship between DI-GM and sleep pathophysiology requires further elucidation. Methods: The data were obtained from the National Health and Nutrition Examination Survey (NHANES) across six cycles over the years 2007 to 2018. We applied logistic regression analyses with multivariable adjustments with sample weighting to assess the independent associations of DI-GM, its beneficial and unfavorable subcomponents, with sleep disorders prevalence, reporting effect estimates as adjusted odds ratios (ORs). We used restricted cubic spline (RCS) models to evaluate relationships between dose and response, and subgroup analyses to explore effect modifications. We used mediation analysis to assess the intermediary role of mLE8 (Modified Life's Essential 8) and all its components. Results: After full adjustment, higher DI-GM and DI-GM beneficial scores were found to be associated with a reduction in sleep disorders (OR: 0.92, 95% CI: 0.86-0.97; OR: 0.90, 95% CI: 0.85-0.96, respectively). Individuals whose DI-GM was 5 or above had a 34% decreased chance of sleep disorders compared to those with scores of 3 or less (OR: 0.66, 95% CI: 0.52-0.85), while DI-GM beneficial scores ≥6 reduced the risk by 35% compared to those with scores ≤1 (OR: 0.65, 95% CI: 0.49-0.85). RCS showed a non-linear negative trend for DI-GM ( Conclusion: Elevated DI-GM and DI-GM beneficial scores are associated with reduced incidence of sleep disorders. mLE8 mediates the associations of both DI-GM and DI-GM beneficial with sleep disorders.
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