ArticleFrontiers in nutrition2025
Dietary Omega-3 fatty acids inversely associated with systemic inflammatory response index (SIRI): a population-based analysis of NHANES 2005-2018.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Article
- Resolution of systemic inflammation in psoriasis following herring roe oil treatment: aFrontiers in medicine · 2026Article
- Lymphocyte to C-reactive protein ratio as a novel inflammatory biomarker: Validation and clinical relevance as an independent prognostic factor in cholangiocarcinoma.World journal of gastrointestinal oncology · 2025Article
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4 authors.
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Abstract
Background: Omega-3 fatty acids are known for their anti-inflammatory and antioxidant properties. However, the relationship between Omega-3 intake and the systemic inflammatory response index (SIRI) remains unclear. This study aimed to examine the potential association between Omega-3 fatty acid intake and SIRI. Methods: A cross-sectional study was conducted using comprehensive data from the National Health and Nutrition Examination Survey (NHANES) for 2005-2018, assessing total Omega-3 fatty acid intake and SIRI among adults. SIRI was calculated using the formula monocyte × neutrophil count/lymphocyte count. The total dietary intake of Omega-3 fatty acids was calculated by summing the intakes of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Subgroup analysis, smoothed curve fitting, and segmented linear regression were employed to investigate the relationship between SIRI and Omega-3 fatty acid consumption across genders. Results: A total of 26,416 participants were included in the study. Participants were classified into quartiles of Omega-3 fatty acid intake: 0-0.014, 0.015-0.037, 0.037-0.093, and 0.093-5.215. The participants' SIRI ranged from 1.242 ± 0.916, with levels decreasing as Omega-3 fatty acid intake quartiles increased (Q1: 1.27 ± 0.88; Q2: 1.27 ± 1.01; Q3: 1.25 ± 0.91; Q4: 1.18 ± 0.87, Conclusion: A negative association may exist between SIRI and the consumption of omega-3 fatty. Further extensive studies are still needed to analyze their interaction.
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