ArticleJournal of microscopy and ultrastructure
Clinicopathological Role of Progesterone Hormone in IDH-Mutant Astrocytoma.
Article in Journal of microscopy and ultrastructure. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Context: Sex steroid hormones can influence astrocytomas, the most common form of glioma. Progesterone (P) may participate in cancer development. The current study evaluated the progesterone receptor (PR) expression in 49 (isocitrate dehydrogenase (IDH) mutant) astrocytomas concerning their proliferative potential. Aim: The current study aimed to assess the immunohistochemical progesterone expression in IDH-mutant astrocytic tumors besides correlating such expression with the pathological parameters of the tumors. Settings and Design: This is a retrospective observational cross-sectional study. Materials and Methods: Forty-nine intracranial astrocytoma specimens were evaluated for PRs and isocitrate dehydrogenase (IDH) enzyme mutations in a histopathological and immunohistochemical study. Results: The study included 26 females (53.1%) and 23 males (46.9%) ( Conclusion: We propose a correlation between PR and the histologic grade, growth, and angiogenesis of the IDH-mutant astrocytoma. As a result, it can act as a prognostic marker for a new promising target therapy.
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